Differential regulation of the SMN2 gene by individual HDAC proteins.

@article{Evans2011DifferentialRO,
  title={Differential regulation of the SMN2 gene by individual HDAC proteins.},
  author={Matthew Charles Evans and Jonathan J. Cherry and Elliot J Androphy},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={414 1},
  pages={
          25-30
        }
}
Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder that is the leading genetic cause of infantile death. SMA is caused by homozygous deletion or mutation of the survival of motor neuron 1 gene (SMN1). The SMN2 gene is nearly identical to SMN1, however is alternatively spliced. The close relationship to SMN1 results in SMN2 being a very power genetic modifier of SMA disease severity and a target for therapies. We sought to identify the regulatory role individual… CONTINUE READING
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