Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.

@article{Groom1996DifferentialRO,
  title={Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.},
  author={L A Groom and A A Sneddon and Dario R Alessi and Stephen Dowd and Stephen M. Keyse},
  journal={The EMBO journal},
  year={1996},
  volume={15 14},
  pages={3621-32}
}
The Pyst1 and Pyst2 mRNAs encode closely related proteins, which are novel members of a family of dual-specificity MAP kinase phosphatases typified by CL100/MKP-1. Pyst1 is expressed constitutively in human skin fibroblasts and, in contrast to other members of this family of enzymes, its mRNA is not inducible by either stress or mitogens. Furthermore… CONTINUE READING