Differential regulation of synaptic vesicle proteins by antidepressant drugs

  title={Differential regulation of synaptic vesicle proteins by antidepressant drugs},
  author={Simone Rapp and Miriam Baader and M Hu and Christine Jennen-Steinmetz and Fritz A. Henn and Johannes Thome},
  journal={The Pharmacogenomics Journal},
ABSTRACTSynaptic vesicle proteins (SVP) play a critical role in neurotransmitter release and neural plasticity, and have been implicated in the pathophysiology of psychiatric disorders such as depression. Antidepressant drugs not only alter the level of neurotransmitters, but also modulate de novo gene transcription and synthesis of proteins involved in neural plasticity. In order to investigate the effects of antidepressant compounds on SVP-mRNA levels, the expressions of synaptophysin… CONTINUE READING
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