Differential regulation of somatostatin receptor type 2 (sst 2) expression in AR4-2J tumor cells implanted into mice during octreotide treatment.

@article{Froidevaux1999DifferentialRO,
  title={Differential regulation of somatostatin receptor type 2 (sst 2) expression in AR4-2J tumor cells implanted into mice during octreotide treatment.},
  author={Sylvie Froidevaux and Edith Hintermann and Mikl{\'o}s T{\"o}r{\"o}k and Helmut R. Maecke and Christoph Beglinger and Alex N. Eberle},
  journal={Cancer research},
  year={1999},
  volume={59 15},
  pages={
          3652-7
        }
}
Octreotide is a somatostatin analogue that is widely used for cancer therapy and tumor imaging. Its efficacy in tumors depends mainly on the expression of the somatostatin receptor type 2 (sst 2). Desensitization and down-regulation of sst 2 after agonist exposure can have important consequences for patients under ongoing octreotide therapy because it may induce temporary tumor unresponsiveness and impair sst 2-based tumor scintigraphy. Therefore, we have investigated the effect of octreotide… CONTINUE READING

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