Differential regulation of single CFTR channels by PP2C, PP2A, and other phosphatases.

@article{Luo1998DifferentialRO,
  title={Differential regulation of single CFTR channels by PP2C, PP2A, and other phosphatases.},
  author={Jiexin Luo and Mary D. Pato and John R. Riordan and John W. Hanrahan},
  journal={The American journal of physiology},
  year={1998},
  volume={274 5 Pt 1},
  pages={
          C1397-410
        }
}
Cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel activity declines rapidly when excised from transfected Chinese hamster ovary (CHO) or human airway cells because of membrane-associated phosphatase activity. In the present study, we found that CFTR channels usually remained active in patches excised from baby hamster kidney (BHK) cells overexpressing CFTR. Those patches with stable channel activity were used to investigate the regulation of CFTR by exogenous protein… CONTINUE READING
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