Differential regulation of protein subdomain activity with caged bivalent ligands.

Abstract

Subtle change: Spatiotemporal modulation of individual protein subdomains with light as the trigger signal becomes possible by using bivalent aptamers and introducing photolabile "caging groups" to switch individual aptamer modules ON or OFF differentially. To the best of our knowledge, this is the first study to show that it is possible to modulate… (More)
DOI: 10.1002/cbic.200800814

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