Differential regulation of protein- and polysaccharide-specific Ig isotype production in vivo in response to intact Streptococcus pneumoniae.

@article{Snapper2006DifferentialRO,
  title={Differential regulation of protein- and polysaccharide-specific Ig isotype production in vivo in response to intact Streptococcus pneumoniae.},
  author={Clifford M Snapper},
  journal={Current protein & peptide science},
  year={2006},
  volume={7 4},
  pages={
          295-305
        }
}
Adaptive humoral immunity to extracellular bacteria is largely mediated by antibody specific for both protein and polysaccharide antigens. Proteins and polysaccharides are biochemically distinct, and as a result are processed differently by the immune system, leading to different mechanistic pathways for eventual elicitation of specific Ig isotypes. Much of our current knowledge concerning the parameters underlying anti-protein and anti-polysaccharide Ig responses have come from studies using… CONTINUE READING

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Streptococcus pneumoniae. Molecular Biology and Mechanisms of Disease (Tomasz, A., Ed.)

  • W. Fischer
  • 2000
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