Differential regulation of prolactin release and lactotrope proliferation during pregnancy, lactation and the estrous cycle.

@article{Yin2000DifferentialRO,
  title={Differential regulation of prolactin release and lactotrope proliferation during pregnancy, lactation and the estrous cycle.},
  author={Ping Yin and Jun Arita},
  journal={Neuroendocrinology},
  year={2000},
  volume={72 2},
  pages={72-9}
}
The proestrous surge of prolactin (PRL) secretion and subsequent proliferation of lactotropes at estrus have been suggested to be induced by a common hypothalamic hormone. We investigated changes in lactotrope proliferation at other reproductive stages of female rats when PRL secretion was stimulated. To assess proliferative activity of lactotropes, incorporation of 5-bromo-2'-deoxyuridine (BrdU) into DNA was measured by double immunostaining for PRL and BrdU. BrdU-labeling indices, determined… CONTINUE READING