Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.

@article{Shin2012DifferentialRO,
  title={Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.},
  author={Jinwook Shin and Thomas Francis O'brien and Jason M. Grayson and Xiao-Ping Zhong},
  journal={Journal of immunology},
  year={2012},
  volume={188 5},
  pages={
          2111-7
        }
}
The manipulation of signals downstream of the TCR can have profound consequences for T cell development, function, and homeostasis. Diacylglycerol (DAG) produced after TCR stimulation functions as a secondary messenger and mediates the signaling to Ras-MEK-Erk and NF-κB pathways in T cells. DAG kinases (DGKs) convert DAG into phosphatidic acid, resulting in termination of DAG signaling. In this study, we demonstrate that DAG metabolism by DGKs can serve a crucial function in viral clearance… CONTINUE READING
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