Differential regulation of perforin expression in human CD4+ and CD8+ cytotoxic T lymphocytes.

@article{Niiya2005DifferentialRO,
  title={Differential regulation of perforin expression in human CD4+ and CD8+ cytotoxic T lymphocytes.},
  author={Hironari Niiya and Ikuya Sakai and Jin Lei and Taichi Azuma and Naoyuki Uchida and Yoshihiro Yakushijin and Takaaki Hato and Shigeru Fujita and Masaki Yasukawa},
  journal={Experimental hematology},
  year={2005},
  volume={33 7},
  pages={811-8}
}
OBJECTIVE Because perforin is an essential cytolytic mediator of cytotoxic T lymphocytes (CTLs), it is important to understand the regulatory mechanisms of perforin expression in CTLs. In the present study, we investigated the relationship between cytotoxic activity, perforin expression, and cell-activated status of CD4(+) and CD8(+) CTLs. METHODS Herpes… CONTINUE READING