Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes

@inproceedings{Sekine2012DifferentialRO,
  title={Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes},
  author={Chiyoko Sekine and Akemi Koyanagi and Noriko Koyama and Katsuto Hozumi and Shigeru Chiba and H. Yagita},
  booktitle={Arthritis research & therapy},
  year={2012}
}
INTRODUCTION Osteoclastogenesis plays an important role in the bone erosion of rheumatoid arthritis (RA). Recently, Notch receptors have been implicated in the development of osteoclasts. However, the responsible Notch ligands have not been identified yet. This study was undertaken to determine the role of individual Notch receptors and ligands in osteoclastogenesis. METHODS Mouse bone marrow-derived macrophages or human peripheral blood monocytes were used as osteoclast precursors and… CONTINUE READING

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