Differential regulation of nitric oxide synthase isoforms in experimental acute chagasic cardiomyopathy.

@article{Chandrasekar2000DifferentialRO,
  title={Differential regulation of nitric oxide synthase isoforms in experimental acute chagasic cardiomyopathy.},
  author={Bysani Chandrasekar and Peter C Melby and Dean A. Troyer and Gregory L. Freeman},
  journal={Clinical and experimental immunology},
  year={2000},
  volume={121 1},
  pages={112-9}
}
We have previously demonstrated induction and high level expression of IL-1beta, IL-6 and tumour necrosis factor-alpha in the myocardium during the acute stage of experimental Trypanosoma cruzi infection (Chagas' disease). The myocardial depressive effects of these cytokines are mediated in part by the induction of nitric oxide synthase (NOS), production of nitric oxide (NO) and formation of peroxynitrite. In this study we investigated the expression, activity and localization of NOS isoforms… CONTINUE READING
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