Differential regulation of neuropeptide Y receptors in the brains of NPY knock-out mice.

@article{Trivedi2001DifferentialRO,
  title={Differential regulation of neuropeptide Y receptors in the brains of NPY knock-out mice.},
  author={Prashant Trivedi and H Yu and Myrna E. Trumbauer and H Chen and Lex H. T. van der Ploeg and X M Guan},
  journal={Peptides},
  year={2001},
  volume={22 3},
  pages={395-403}
}
To study the effect of NPY deletion on the regulation of its receptors in the NPY knockout (NPY KO) mice, the expression and binding of NPY receptors were investigated by in situ hybridization and receptor autoradiography using (125)I-[Leu(31),Pro(34)]PYY and (125)I-PYY(3-36) as radioligands. A 6-fold increase in Y2 receptor mRNA was observed in the CA1 region of the hippocampus in NPY KO mice, but a significant change could not be detected for Y1, Y4, Y5 and y6 receptors. Receptor binding… CONTINUE READING