Differential regulation of nerve growth factor and brain-derived neurotrophic factor in a mouse model of learned helplessness.

@article{SchulteHerbrggen2006DifferentialRO,
  title={Differential regulation of nerve growth factor and brain-derived neurotrophic factor in a mouse model of learned helplessness.},
  author={Olaf Schulte-Herbr{\"u}ggen and Sabine Chourbaji and H Mueller and Heidi Danker-Hopfe and Christiane Brandwein and Peter Gass and Rainer Hellweg},
  journal={Experimental neurology},
  year={2006},
  volume={202 2},
  pages={404-9}
}
Stress-induced helplessness in rodents constitutes a well-defined model to investigate neurobiological mechanisms of depression. Neurotrophins like nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) have both been shown to be involved in neurobiological changes of physiological and pathological reactions to stress. In this study we investigated NGF and BDNF protein levels in the frontal cortex and hippocampus in mice treated with an established model of inducible… CONTINUE READING