Differential regulation of natriuretic peptide receptor messenger RNAs during the development of cardiac hypertrophy in the rat.

@article{Brown1993DifferentialRO,
  title={Differential regulation of natriuretic peptide receptor messenger RNAs during the development of cardiac hypertrophy in the rat.},
  author={Lesley A. Brown and D. J. Nunez and Martin R. Wilkins},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={92 6},
  pages={
          2702-12
        }
}
The heart expresses the three natriuretic peptide receptors (NPR), namely NPR-A, NPR-B, and NPR-C. We have examined the temporal relationship between the expression of mRNA transcripts for atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) and their receptors in the heart during the development of cardiac hypertrophy in the aortovenocaval fistula rat. Messenger RNAs were measured by cDNA amplification. Progressive cardiac hypertrophy was accompanied by increased ANP mRNA… 
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Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy.
TLDR
The data suggest that pressure overload is accompanied by upregulation of not only ANP and BNP but also their receptors NPR-A and NPR-C in the left ventricle in rats with pressure-overload cardiac hypertrophy.
Downregulation of natriuretic peptide C-receptor protein in the hypertrophied ventricle of the aortovenocaval fistula rat.
Differential expression of natriuretic peptides and their receptors in volume overload cardiac hypertrophy in the rat.
TLDR
The disparate response of BNP and the NP clearance receptor transcript levels in the LV and RV may be related to differences in load and/or differential expression of the NP system in theLV and RV in response to acute haemodynamic stress.
Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression
B-type natriuretic peptide receptors in hypertrophied adult rat cardiomyocytes.
Messenger RNAs encoding the natriuretic peptides and their receptors are expressed in the eye.
The expression and secretion of atrial natriuretic factor and brain natriuretic peptide by rat proximal tubular cells.
Cardiac-specific attenuation of natriuretic peptide A receptor activity accentuates adverse cardiac remodeling and mortality in response to pressure overload.
TLDR
Ex vivo studies show that endogenous natriuretic peptides exert physiologically relevant autocrine and paracrine effects via cardiomyocyte NPRA receptors to modulate cardiac hypertrophy and fibrosis in response to pressure overload.
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system.
TLDR
It is concluded that NPRC modulates the availability of the natriuretic peptides at their target organs, thereby allowing the activity of thenatriureic peptide system to be tailored to specific local needs.
Quantification of Low Abundance Natriuretic Peptide Receptor mRNA in Rat Tissues
TLDR
The evaluated method allows the reliable quantification of the specific mRNA expression of all three NPRs with small amounts of RNA and showed that the NPR-A mRNA expression was the most abundant of the three natriuretic peptide receptor mRNAs in rat lungs, glomeruli and left ventricles.
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References

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TLDR
The technique of cDNA amplification with the polymerase chain reaction is employed to confirm the presence of natriuretic peptide A, B, and C receptor mRNAs in rat and human cardiac tissue.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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