Differential regulation of matrix metalloproteinase-3 gene expression in endometriotic lesions compared with endometrium.

@article{Cox2001DifferentialRO,
  title={Differential regulation of matrix metalloproteinase-3 gene expression in endometriotic lesions compared with endometrium.},
  author={Kathryn E Cox and Marta Rabelo Piva and Kathy L. Sharpe-Timms},
  journal={Biology of reproduction},
  year={2001},
  volume={65 4},
  pages={1297-303}
}
In vivo levels of mRNA and the specificity of the extrauterine environment on matrix metalloproteinase (MMP)-3, MMP-2, and tissue inhibitor of matrix metalloproteinase (TIMP)-1 were evaluated in eutopic and ectopic endometrial tissue during the establishment of endometriosis in a rat model. Uteri and endometriotic implants were collected and frozen at 36 h, 2 wk, and 4 wk postsurgery to study in vivo mRNA levels. Intact uteri, uterine tissues implanted in the peritoneum or under the skin, and… CONTINUE READING