Differential regulation of matrix metalloproteinase-9 by monocytes adherent to collagen and platelets.

@article{Galt2001DifferentialRO,
  title={Differential regulation of matrix metalloproteinase-9 by monocytes adherent to collagen and platelets.},
  author={Spencer W Galt and Stefan. Lindemann and D Medd and Loren Allen and Larry W. Kraiss and Estelle S. Harris and Stephen M. Prescott and Thomas M McIntyre and Andrew S. Weyrich and Guy A. Zimmerman},
  journal={Circulation research},
  year={2001},
  volume={89 6},
  pages={509-16}
}
Circulating monocytes adhere to platelets and matrix proteins at sites of vascular injury, where engagement of specific surface tethering molecules mediates outside-in signaling and synthesis of gene products by the leukocytes. Here we demonstrate that interaction of isolated human monocytes with collagen induces matrix metalloproteinase-9 (MMP-9; gelatinase B) synthesis by monocytes, a process that is greatly enhanced in the presence of platelets. MMP-9 is a potent matrix degrading enzyme… CONTINUE READING

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