Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen.

@article{Hsieh2017DifferentialRO,
  title={Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen.},
  author={Jessica Y Hsieh and Tim J D Smith and Vijaykumar S. Meli and Thi Nhu Thuy Tran and Elliot L. Botvinick and Wendy Liu},
  journal={Acta biomaterialia},
  year={2017},
  volume={47},
  pages={14-24}
}
Fibrin is a major component of the provisional extracellular matrix formed during tissue repair following injury, and enables cell infiltration and anchoring at the wound site. Macrophages are dynamic regulators of this process, advancing and resolving inflammation in response to cues in their microenvironment. Although much is known about how soluble factors such as cytokines and chemokines regulate macrophage polarization, less is understood about how insoluble and adhesive cues, specifically… CONTINUE READING