Differential regulation of key stages in early corneal wound healing by TGF-beta isoforms and their inhibitors.

@article{Carrington2006DifferentialRO,
  title={Differential regulation of key stages in early corneal wound healing by TGF-beta isoforms and their inhibitors.},
  author={Louise M Carrington and Julie Albon and Ian Jacob Anderson and Christina Kamma and Mike Boulton},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 5},
  pages={1886-94}
}
PURPOSE Inhibition of TGF-beta reduces myofibroblast differentiation and fibrosis in the cornea. Determining the actions of distinct TGF-beta isoforms and their inhibitors during early corneal wound healing is an essential step in guiding therapeutic intervention. METHODS Bovine serum-free corneal cell and wounded organ cultures were challenged with a range of concentrations of TGF-beta1, -beta2, and -beta3; IL-10; and neutralizing human monoclonal antibodies (mAbs) against TGF-beta1 (CAT-192… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

HGF and KGF regulate both epithelial and stromal corneal wound healing

  • L Carrington, M. Boulton
  • J Cataract Refract Surg
  • 2005
2 Excerpts

Similar Papers

Loading similar papers…