Differential regulation of human immunodeficiency viruses (HIVs): a specific regulatory element in HIV-2 responds to stimulation of the T-cell antigen receptor.

@article{Markovitz1990DifferentialRO,
  title={Differential regulation of human immunodeficiency viruses (HIVs): a specific regulatory element in HIV-2 responds to stimulation of the T-cell antigen receptor.},
  author={David M. Markovitz and Mark C. Hannibal and V{\'i}ctor L. P{\'e}rez and Charles J. Gauntt and Thomas M. Folks and Gary J. Nabel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 23},
  pages={9098-102}
}
The human immunodeficiency viruses (HIVs) types 1 and 2 have similar genetic organization but differ significantly in nucleic acid sequence. Although infection by either agent leads to symptoms of immunodeficiency, recent studies suggest potential differences in the time course and severity of these diseases. In this report, the transcriptional regulation and induction of these retroviruses were analyzed. We report that the regulation of HIV-2 differs from that of HIV-1: a distinct T-cell… CONTINUE READING

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