Differential regulation of human alveolar macrophage-derived interleukin-1beta and tumor necrosis factor-alpha by iron.

@article{OBrienLadner1998DifferentialRO,
  title={Differential regulation of human alveolar macrophage-derived interleukin-1beta and tumor necrosis factor-alpha by iron.},
  author={Amy R. O'Brien-Ladner and B M Blumer and Lewis Jon Wesselius},
  journal={The Journal of laboratory and clinical medicine},
  year={1998},
  volume={132 6},
  pages={497-506}
}
Human lungs accumulate iron with the aging process. In some circumstances associated with lung injury (eg, smoking), this acquisition of iron in lung tissue and alveolar macrophages (AMs) is escalated. We hypothesized that excess cellular iron interfered with the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1-beta) by AMs. To examine this hypothesis, we acquired AMs from smokers and nonsmokers by bronchoalveolar lavage. AMs were stimulated by… CONTINUE READING

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