Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro.

@article{Maeda2009DifferentialRO,
  title={Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro.},
  author={Eijiro Maeda and Julia C Shelton and Dan L. Bader and David A Lee},
  journal={Journal of applied physiology},
  year={2009},
  volume={106 2},
  pages={
          506-12
        }
}
Mechanical stimulus is a regulator of tenocyte metabolism. The present study investigated temporal regulation of the expression of selected genes by tenocytes in isolated fascicles subjected to tensile strain in vitro. Cyclic tensile strain with a 3% amplitude superimposed on a 2% static strain was provided for 10 min, followed by either an unstrained period or continuous cyclic strain until the end of a 24-h incubation period. mRNA expression of selected anabolic and catabolic genes were… CONTINUE READING

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Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading.

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