Differential regulation of expression of three transforming growth factor beta species in human breast cancer cell lines by estradiol.

@article{Arrick1990DifferentialRO,
  title={Differential regulation of expression of three transforming growth factor beta species in human breast cancer cell lines by estradiol.},
  author={Bradley A Arrick and Murray Korc and Rik Derynck},
  journal={Cancer research},
  year={1990},
  volume={50 2},
  pages={299-303}
}
Transforming growth factor (TGF)-beta is a potent regulator of many cell functions and a growth inhibitor for mammary epithelial cells. We now know of three highly homologous members of the human TGF-beta gene family. We have studied the expression of TGF-beta 1, -beta 2, and -beta 3 mRNA in four human breast cancer cell lines. Using the RNase protection assay, we have detected mRNA expression of TGF-beta 1, -beta 2, and -beta 3 by T-47D cells, TGF-beta 1 and -beta 3 by ZR-75-1 cells, and TGF… CONTINUE READING
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