Differential regulation of estrogen receptor alpha turnover and transactivation by Mdm2 and stress-inducing agents.

@article{Duong2007DifferentialRO,
  title={Differential regulation of estrogen receptor alpha turnover and transactivation by Mdm2 and stress-inducing agents.},
  author={Vanessa Duong and Nathalie Boulle and Sylvain Daujat and J{\'e}r{\^o}me Chauvet and Sandrine Bonnet and Henry Neel and Vincent Cavaill{\`e}s},
  journal={Cancer research},
  year={2007},
  volume={67 11},
  pages={5513-21}
}
In mammalian cells, the level of estrogen receptor alpha (ERalpha) is rapidly decreased upon estrogen treatment, and this regulation involves proteasome degradation. Using different approaches, we showed that the Mdm2 oncogenic ubiquitin-ligase directly interacts with ERalpha in a ternary complex with p53 and is involved in the regulation of ERalpha turnover (both in the absence or presence of estrogens). Several lines of evidence indicated that this effect of Mdm2 required its ubiquitin-ligase… CONTINUE READING

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