Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1.

@article{Kang2014DifferentialRO,
  title={Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1.},
  author={Hyun-Jin Kang and Min-Ho Lee and H. Kang and Sung-hye Kim and Jung-Ranh Ahn and Hyelin Na and Tae-Young Na and Yo Na Kim and Je Kyung Seong and M H Lee},
  journal={Cancer research},
  year={2014},
  volume={74 5},
  pages={1484-94}
}
Metastasis-associated protein 1 (MTA1) is a component of the nucleosome remodeling and histone deacetylase (HDAC) complex, which plays an important role in progression of breast cancer. Although MTA1 is known as a repressor of the transactivation function of estrogen receptor α (ERα), its involvement in the epigenetic control of transcription of the ERα gene ESR1 has not been studied. Here, we show that silencing of MTA1 reduced the level of expression of ERα in ERα-positive cells but increased… CONTINUE READING
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