Differential regulation of epidermal and dermal dendritic cells by IL-12 and Flt3 ligand.

Abstract

An abrogation of the decline in epidermal Langerhans cell numbers above melanoma might significantly improve the efficacy of immunotherapy for melanoma treatment. Systemic Flt3 ligand (FL) administration in mice induced a significant increase in mature dendritic cells (DC) within the skin, preferentially in the dermis, whereas IL-12 promoted a significant… (More)

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@article{Esche1999DifferentialRO, title={Differential regulation of epidermal and dermal dendritic cells by IL-12 and Flt3 ligand.}, author={Christoph Esche and Vladimir M. Subbotin and Oriana C Hunter and Jean Marc Peron and Charles R. Maliszewski and M. T. Lotze and M. R. Shurin}, journal={The Journal of investigative dermatology}, year={1999}, volume={113 6}, pages={1028-32} }