Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3.

@article{Surapisitchat2007DifferentialRO,
  title={Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3.},
  author={James Surapisitchat and Kye-Im Jeon and Chen Yan and Joseph A. Beavo},
  journal={Circulation research},
  year={2007},
  volume={101 8},
  pages={811-8}
}
Endothelial barrier dysfunction leading to increased permeability and vascular leakage is an underlying cause of several pathological conditions, including edema and sepsis. Whereas cAMP has been shown to decrease endothelial permeability, the role of cGMP is controversial. Endothelial cells express cGMP-inhibited phosphodiesterase (PDE)3A and cGMP-stimulated PDE2A. Thus we hypothesized that the effect of cGMP on endothelial permeability is dependent on the concentration of cGMP present and on… CONTINUE READING

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