Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction.

@article{Amarilio2005DifferentialRO,
  title={Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction.},
  author={Roy Amarilio and Sreekumar Ramachandran and Helena Sabanay and Sima Lev},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 7},
  pages={5934-44}
}
The endoplasmic reticulum (ER) exhibits a characteristic tubular structure that is dynamically rearranged in response to specific physiological demands. However, the mechanisms by which the ER maintains its characteristic structure are largely unknown. Here we show that the integral ER-membrane protein VAP-B causes a striking rearrangement of the ER through interaction with the Nir2 and Nir3 proteins. We provide evidence that Nir (Nir1, Nir2, and Nir3)-VAP-B interactions are mediated through… CONTINUE READING