Differential regulation of elevated renal angiotensin II in chronic renal ischemia.

@article{Tokuyama2002DifferentialRO,
  title={Differential regulation of elevated renal angiotensin II in chronic renal ischemia.},
  author={Hirobumi Tokuyama and Koichi Hayashi and Hiroto Matsuda and Eiji Kubota and Masanori Honda and Ken Okubo and Ichiro Takamatsu and Satoru Tatematsu and Yuri Ozawa and Shu Wakino and Takao Saruta},
  journal={Hypertension},
  year={2002},
  volume={40 1},
  pages={34-40}
}
The present study was undertaken to clarify the role of intrarenal angiotensin (Ang) II and its generating pathways in clipped and nonclipped kidneys of 4-week unilateral renal artery stenosis in anesthetized dogs. After 4 weeks, renal plasma flow (RPF) decreased in clipped and nonclipped kidneys (baseline, 59+/-3; clipped, 16+/-1; nonclipped, 44+/-2 mL/min; P<0.01, n=22). Renal Ang I levels increased only in clipped, whereas intrarenal Ang II contents were elevated in both clipped (from 0.7… CONTINUE READING