Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons.

  title={Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons.},
  author={Miho Hamada and Hideho Higashi and Angus C. Nairn and Paul Greengard and Akinori Nishi},
  journal={Journal of neurochemistry},
  volume={90 5},
Nicotine, acting on nicotinic acetylcholine receptors (nAChRs) expressed at pre-synaptic dopaminergic terminals, has been shown to stimulate the release of dopamine in the neostriatum. However, the molecular consequences of pre-synaptic nAChR activation in post-synaptic neostriatal neurons are not clearly understood. Here, we investigated the effect of nAChR activation on dopaminergic signaling in medium spiny neurons by measuring phosphorylated DARPP-32 (dopamine- and cAMP-regulated… CONTINUE READING


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