Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo.

@article{Dietz2013DifferentialRO,
  title={Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo.},
  author={Birgit M Dietz and Ghenet K Hagos and Jillian N. Eskra and Gihani T Wijewickrama and Jeffrey R. Anderson and Dejan Nikoli{\'c} and Jian Guo and Brian Wright and Shao-Nong Chen and Guido F Pauli and Richard B van Breemen and Judy L Bolton},
  journal={Molecular nutrition & food research},
  year={2013},
  volume={57 6},
  pages={
          1055-66
        }
}
SCOPE Hops contain the phytoestrogen, 8-prenylnaringenin, and the cytoprotective compound, xanthohumol (XH). XH induces the detoxification enzyme, NAD(P)H-quinone oxidoreductase (NQO1) in vitro; however, the tissue distribution of XH and 8-prenylnaringenin and their tissue-specific activity have not been analyzed. METHODS AND RESULTS An orally administered hop extract and subcutaneously injected XH were administered to Sprague-Dawley rats over 4 days. LC-MS-MS analysis of plasma, liver, and… CONTINUE READING
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