Differential regulation of cortactin and N-WASP-mediated actin polymerization by missing in metastasis (MIM) protein

Abstract

Missing in metastasis (MIM) gene encodes an actin binding protein that is expressed at low levels in a subset of malignant cell lines. MIM protein tagged by green fluorescent protein (GFP) colocalizes with cortactin, an Arp2/3 complex activator, and interacts directly with the SH3 domain of cortactin. Recombinant full-length MIM promotes markedly cortactin… (More)
DOI: 10.1038/sj.onc.1208412

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