Differential regulation of components of the focal adhesion complex by heregulin: role of phosphatase SHP-2.

@article{Vadlamudi2002DifferentialRO,
  title={Differential regulation of components of the focal adhesion complex by heregulin: role of phosphatase SHP-2.},
  author={Ratna K Vadlamudi and Liana Adam and Diep D. Nguyen and Manes Santos and Rakesh Kumar},
  journal={Journal of cellular physiology},
  year={2002},
  volume={190 2},
  pages={189-99}
}
Heregulin (HRG) has been implicated in the progression of breast cancer cells to a malignant phenotype, a process that involves changes in cell motility and adhesion. Here we demonstrate that HRG differentially regulates the site-specific phosphorylation of the focal adhesion components focal adhesion kinase (FAK) and paxilin in a dose-dependent manner. HRG at suboptimal doses (0.01 and 0.1 nM) increased adhesion of cells to the substratum, induced phosphorylation of FAK at Tyr-577, -925, and… CONTINUE READING
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