Differential regulation of c-Rel translocation in activated B and T cells.

@article{Venkataraman1996DifferentialRO,
  title={Differential regulation of c-Rel translocation in activated B and T cells.},
  author={Lalgudi Venkataraman and W Wang and Ranjan Sen},
  journal={Journal of immunology},
  year={1996},
  volume={157 3},
  pages={1149-55}
}
c-Rel induction in activated lymphocytes is suppressed by the immunosuppressive drug, FK506. Here we show that FK506-suppressible, delayed c-Rel induction is similar in B and T cells and is regulated by mRNA production. In contrast, rapid nuclear translocation of pre-existing cytoplasmic c-Rel occurs only in B cells, but not in T cells. Analysis of I-kappaBalpha and -beta in these cells showed that both I-kappaBalpha and I-kappaBbeta were rapidly degraded in response to stimulation in B cells… CONTINUE READING