Differential regulation of breast tumor cell proliferation by stromal fibroblasts of various breast tissue sources.

@article{Roozendaal1996DifferentialRO,
  title={Differential regulation of breast tumor cell proliferation by stromal fibroblasts of various breast tissue sources.},
  author={Kees E. P. van Roozendaal and Jan G. M. Klijn and Bart van Ooijen and Cassandra J. C. Claassen and Alexander Eggermont and Sonja C. Henzen-Logmans and John A. Foekens},
  journal={International journal of cancer},
  year={1996},
  volume={65 1},
  pages={120-5}
}
A stromal fibroblast-mediated paracrine regulation of epithelial tumor cell proliferation and differentiation plays an important role in the development and progression of breast tumors. We have studied the paracrine growth regulation of various phenotypically different breast cancer cell lines using conditioned serum-free media (C-SFM) from primary breast fibroblasts. Fibroblast cultures were established from malignant primary tumors and adjacent normal breast tissue, benign fibroadenomas… CONTINUE READING