Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.

@article{Li2012DifferentialRO,
  title={Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.},
  author={Jie Li and Takahisa Kanekiyo and Mitsuru Shinohara and Yunwu Zhang and Mary Jo Ladu and Huaxi Xu and Guojun Bu},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 53},
  pages={44593-601}
}
Aggregation of amyloid-β (Aβ) peptides leads to synaptic disruption and neurodegeneration in Alzheimer disease (AD). A major Aβ clearance pathway in the brain is cellular uptake and degradation. However, how Aβ traffics through the endocytic pathway and how AD risk factors regulate this event is unclear. Here we show that the majority of endocytosed Aβ in neurons traffics through early and late endosomes to the lysosomes for degradation. Overexpression of Rab5 or Rab7, small GTPases that… CONTINUE READING
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