Differential regulation of active zone density during long-term strengthening of Drosophila neuromuscular junctions.

@article{Reiff2002DifferentialRO,
  title={Differential regulation of active zone density during long-term strengthening of Drosophila neuromuscular junctions.},
  author={Dierk F. Reiff and Philippe R. Thiel and Christoph Maria Schuster},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 21},
  pages={9399-409}
}
In this study we established a transgenic Ca2+ imaging technique in Drosophila that enabled us to target the Ca2+ sensor protein yellow Cameleon-2 specifically to larval neurons. This noninvasive method allowed us to measure evoked Ca2+ signals in presynaptic terminals of larval neuromuscular junctions (NMJs). We combined transgenic Ca2+ imaging with electrophysiological recordings and morphological examinations of larval NMJs to analyze the mechanisms underlying persistently enhanced evoked… CONTINUE READING