Differential regulation of a glial fibrillary acidic protein-LacZ transgene in retinal astrocytes and Müller cells.

@article{Verderber1995DifferentialRO,
  title={Differential regulation of a glial fibrillary acidic protein-LacZ transgene in retinal astrocytes and M{\"u}ller cells.},
  author={L C Verderber and Willis Johnson and Lennart Mucke and Vijay P. Sarthy},
  journal={Investigative ophthalmology & visual science},
  year={1995},
  volume={36 6},
  pages={1137-43}
}
PURPOSE Glial fibrillary acidic protein (GFAP) is normally expressed in astrocytes, but not in Müller cells, in the mouse retina. In response to retinal injury or photoreceptor degeneration, however, GFAP gene transcription is strongly activated in the Müller cell. To identify the genetic elements involved in GFAP gene induction, the authors have studied gene expression in transgenic mice in which beta-galactosidase (beta-gal) expression is under control of GFAP regulatory sequences. METHODS… CONTINUE READING

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