Differential regulation of VEGF, HIF1alpha and angiopoietin-1, -2 and -4 by hypoxia and ionizing radiation in human glioblastoma.

@article{Lund2004DifferentialRO,
  title={Differential regulation of VEGF, HIF1alpha and angiopoietin-1, -2 and -4 by hypoxia and ionizing radiation in human glioblastoma.},
  author={Eva L\obner Lund and Anja M H\og and Minna W Br{\ae}ndholt Olsen and Lasse Hansen and Svend Aage Engelholm and Paul E. G. Kristjansen},
  journal={International journal of cancer},
  year={2004},
  volume={108 6},
  pages={833-8}
}
We examined how ionizing radiation (IR) delivered under either severe hypoxia (< 0.1% O2) or normoxia affects the expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the angiogenic factors vascular endothelial growth factor (VEGF) and angiopoietins 1, 2 and 4 in U87 human glioblastoma cells. IR was delivered as single doses of 0, 2, 5, 10 and 20 Gy after 6-hr hypoxic incubation and in normoxic controls. Irradiation at any dose did not affect the cellular protein levels of any of the… CONTINUE READING