Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections

@article{Boettcher2003DifferentialRO,
  title={Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections},
  author={Tobias Boettcher and Matthias von Mering and Sandra Ebert and Uta Meyding-Lamad{\'e} and Roland Nau},
  journal={Neuroscience Letters},
  year={2003},
  volume={344},
  pages={17-20}
}
Toll-like receptors (TLR) play a key role in the recognition of microbial components. We investigated the differential regulation of TLR mRNA expression in bacterial and viral mouse models of central nervous system infection. Streptococcus pneumoniae meningitis led to an enhanced expression of TLR2, TLR4 and TLR9 mRNA. In Escherichia coli meningitis, TLR2, TLR4 and TLR7 mRNA expression was increased and Herpes simplex encephalitis caused a rise of TLR4 mRNA. In organotypic hippocampal cultures… CONTINUE READING

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