Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction

@article{DelloStritto2016DifferentialRO,
  title={Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction},
  author={Daniel J. DelloStritto and Patrick J. Connell and Gregory M. Dick and Ibra S Fancher and Brittany Klarich and Joseph N. Fahmy and Patrick T. Kang and Yeong-Renn Chen and Derek S Damron and Charles Kumar Thodeti and Ian N Bratz},
  journal={Basic Research in Cardiology},
  year={2016},
  volume={111},
  pages={1-16}
}
We demonstrated previously that TRPV1-dependent coupling of coronary blood flow (CBF) to metabolism is disrupted in diabetes. A critical amount of H2O2 contributes to CBF regulation; however, excessive H2O2 impairs responses. We sought to determine the extent to which differential regulation of TRPV1 by H2O2 modulates CBF and vascular reactivity in diabetes. We used contrast echocardiography to study TRPV1 knockout (V1KO), db/db diabetic, and wild type C57BKS/J (WT) mice. H2O2 dose-dependently… CONTINUE READING
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SHOWING 1-10 OF 66 REFERENCES

Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease.

  • Translational research : the journal of laboratory and clinical medicine
  • 2013
VIEW 1 EXCERPT

Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2012
VIEW 1 EXCERPT