Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine.

@article{Teramoto2005DifferentialRO,
  title={Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine.},
  author={Takayuki Teramoto and Eric J Lambie and Kouichi Iwasaki},
  journal={Cell metabolism},
  year={2005},
  volume={1 5},
  pages={343-54}
}
The transient receptor potential (TRP) channels are implicated in various cellular processes, including sensory signal transduction and electrolyte homeostasis. We show here that the GTL-1 and GON-2 TRPM channels regulate electrolyte homeostasis in the C. elegans intestine. GON-2 is responsible for a large outwardly rectifying current of intestinal cells, and its activity is tightly regulated by intracellular Mg(2+) levels, while GTL-1 mainly contributes to appropriate Mg(2+) responsiveness of… CONTINUE READING