Differential regulation of Streptococcus pneumoniae-induced human MUC5AC mucin expression through distinct MAPK pathways.

@article{Lim2009DifferentialRO,
  title={Differential regulation of Streptococcus pneumoniae-induced human MUC5AC mucin expression through distinct MAPK pathways.},
  author={Jae Hyang Lim and Hyun-jung Kim and Kensei Komatsu and Unhwan Ha and Yuxian Huang and Hirofumi Jono and Soo-Mi Kweon and Jiyun Lee and XiangBin Xu and Gen-sheng Zhang and Huahao Shen and Hirofumi Kai and Wenhong Zhang and Haidong Xu and Jian-Dong Li},
  journal={American journal of translational research},
  year={2009},
  volume={1 3},
  pages={300-11}
}
Human epithelial mucin, the major glycoprotein component of mucus, plays a critical role in host innate defense response against invading microbes by facilitating the mucociliary clearance. Excess mucin production, however, overwhelms the mucociliary clearance, resulting in not only defective mucosal defense but also conductive hearing loss in the middle… CONTINUE READING