Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairment.

@article{Jiang2003DifferentialRO,
  title={Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairment.},
  author={Xiaogang Jiang and Erik Edstrom and Mikael Altun and Brun Ulfhake},
  journal={Aging cell},
  year={2003},
  volume={2 1},
  pages={
          47-57
        }
}
The Shc family of proteins participates in mitogenic and survival signalling through binding to receptor tyrosine kinases. We report here on the expression of Shc in forebrain, spinal cord and hind limb muscles from 30-month-old rats with different degrees of sensorimotor impairment. ShcA (mRNA and protein) is up-regulated in skeletal muscles and spinal cord of aged rats, and this change relates to biological age, i.e. degree of behavioural incapacitation, rather than to chronological age… CONTINUE READING