Differential regulation of P-glycoprotein genes in primary rat hepatocytes by collagen sandwich and drugs.

  • C. K. H. Lee
  • Published 2002 in Journal of cellular biochemistry


P-glycoprotein (Pgp) is a small family of plasma membrane proteins, which are capable of transporting substrates across cell membranes. Class I and II Pgp are able to transport drugs and have been shown to mediate multidrug resistance (MDR). Class III Pgp is a long chain phospholipid transporter and does not mediate MDR. The regulation of all three Pgp… (More)