Differential regulation of MAP kinase, p70S6K, and Akt by contraction and insulin in rat skeletal muscle.

@article{Sherwood1999DifferentialRO,
  title={Differential regulation of MAP kinase, p70S6K, and Akt by contraction and insulin in rat skeletal muscle.},
  author={D J Sherwood and Scott D. Dufresne and Jeffrey F. Markuns and Bentley Cheatham and David E. Moller and Doron Aronson and Laurie J Goodyear},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1999},
  volume={276 5},
  pages={E870-E878}
}
To study the effects of contractile activity on mitogen-activated protein kinase (MAP kinase), p70 S6 kinase (p70S6K), and Akt kinase signaling in rat skeletal muscle, hindlimb muscles were contracted by electrical stimulation of the sciatic nerve for periods of 15 s to 60 min. Contraction resulted in a rapid and transient activation of Raf-1 and MAP kinase kinase 1, a rapid and more sustained activation of MAP kinase and the 90-kDa ribosomal S6 kinase 2, and a dramatic increase in c- fos mRNA… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Regulatory mechanisms of skeletal muscle protein turnover during exercise.

  • Journal of applied physiology
  • 2009
VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Insulin-facilitated increase of muscle protein synthesis after resistance exercise involves a MAP kinase pathway.

  • American journal of physiology. Endocrinology and metabolism
  • 2004
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Regulation of insulin signalling by exercise in skeletal muscle

VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Impact of sarcoglycan complex on mechanical signal transduction in murine skeletal muscle.

  • American journal of physiology. Cell physiology
  • 2006
VIEW 1 EXCERPT
CITES BACKGROUND