Differential regulation of Fas-mediated apoptosis in both thyrocyte and lymphocyte cellular compartments correlates with opposite phenotypic manifestations of autoimmune thyroid disease.

@article{Giordano2001DifferentialRO,
  title={Differential regulation of Fas-mediated apoptosis in both thyrocyte and lymphocyte cellular compartments correlates with opposite phenotypic manifestations of autoimmune thyroid disease.},
  author={Carla Giordano and Pierina Richiusa and Marcello Bagnasco and Giuseppe Pizzolanti and Francesco Di Blasi and M S Sbriglia and Alessandro Mattina and Giampaola Pesce and Paola Montagna and Francesca Capone and Gabriella Misiano and A. Scorsone and Alberto Pugliese and Aldo Galluzzo},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2001},
  volume={11 3},
  pages={233-44}
}
Several mechanisms are probably involved in determining the evolution of autoimmune thyroid disease (AITD) towards either hypothyroidism and the clinical syndrome known as Hashimoto's thyroiditis (HT) or toward hyperthyroidism and the symptoms of Graves' disease (GD). To gain further insight into such mechanisms we performed an exhaustive comparative analysis of the expression of key molecules regulating cell death (Fas, Fas ligand [FasL], Bcl-2) and apoptosis in both thyrocytes and thyroid… CONTINUE READING
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