Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas.

@article{Yunokawa2007DifferentialRO,
  title={Differential regulation of DEC2 among hypoxia-inducible genes in endometrial carcinomas.},
  author={Mayu Yunokawa and Keiji Tanimoto and Hideaki Nakamura and Nobutaka Nagai and Yoshiki Kudo and Takeshi Kawamoto and Yukio Kato and Eiso Hiyama and Keiko Hiyama and Masahiko Nishiyama},
  journal={Oncology reports},
  year={2007},
  volume={17 4},
  pages={
          871-8
        }
}
In this study, we demonstrate an important role of activation of the hypoxia-inducible factor-1 (HIF-1) pathway in endometrial carcinogenesis and tumor phenotype development of endometrial carcinoma, and suggest a unique role of the HIF-1-target gene, differentiated embryo chondrocyte 2 (DEC2), in carcinogenesis. Hypoxia caused an increase in HIF-1alpha protein expression in 4 endometrial carcinoma cell lines. The expressions of its 5 target genes - DEC1, DEC2, carbonic anhydrase-9 (CA9… CONTINUE READING

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