Differential regulation of BACE1 expression by oxidative and nitrosative signals

@inproceedings{Kwak2011DifferentialRO,
  title={Differential regulation of BACE1 expression by oxidative and nitrosative signals},
  author={Young-Don Kwak and Ruishan Wang and Jing Jing Li and Yunwu Zhang and Huaxi Xu and F Liao},
  booktitle={Molecular Neurodegeneration},
  year={2011}
}
It is well established that both cerebral hypoperfusion/stroke and type 2 diabetes are risk factors for Alzheimer's disease (AD). Recently, the molecular link between ischemia/hypoxia and amyloid precursor protein (APP) processing has begun to be established. However, the role of the key common denominator, namely nitric oxide (NO), in AD is largely unknown. In this study, we investigated redox regulation of BACE1, the rate-limiting enzyme responsible for the β-cleavage of APP to Aβ peptides… CONTINUE READING
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