Differential regulation of Akt/protein kinase B isoforms during cell cycle progression.

  title={Differential regulation of Akt/protein kinase B isoforms during cell cycle progression.},
  author={Sung Ji Yun and David F. Tucker and Eun Kyoung Kim and Min Sung Kim and Kee Hun Do and Jung Min Ha and Sun Young Lee and Jeanho Yun and Chi Dae Kim and Morris J Birnbaum and Sun Sik Bae},
  journal={FEBS letters},
  volume={583 4},
Phosphatidylinositol 3-kinase pathways play key regulatory roles in cell cycle progression into S phase. In this study, we demonstrated that Akt1/PKBalpha isoform plays an essential role in G(1)/S transition and proliferation. Cells lacking Akt1/PKBalpha showed an attenuated proliferation as well as G(1)/S transition, whereas cells lacking Akt2/PKBbeta showed normal proliferation and G(1)/S transition. The effect of Akt1/PKBalpha on cell proliferation and G(1)/S transition was completely… CONTINUE READING


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Publications referenced by this paper.
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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase

  • D Stokoe
  • B. Science
  • 1997
Highly Influential
4 Excerpts

Identification and characterization of pleckstrinhomology-domain-dependent and isoenzyme-specific Akt inhibitors

  • Barnett, S.F
  • Biochem. J
  • 2005
1 Excerpt

Role for Akt 3 / protein kinase B c in attainment of normal brain size

  • R. M. Easton
  • Mol . Cell . Biol .
  • 2005

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